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Dot1L-IN-4
CAS No. 2565705-02-2
Dot1L-IN-4 ( N1-[(3-Chloro-pyridin-2-yl)-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-methyl]-4-methanesulfonyl-N2-(4-methoxy-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-benzene-1,2-diamine )
Catalog No. M24155 CAS No. 2565705-02-2
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 250 | In Stock |
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| 5MG | 372 | In Stock |
|
| 10MG | 556 | In Stock |
|
| 25MG | 887 | In Stock |
|
| 50MG | 1197 | In Stock |
|
| 100MG | 1611 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDot1L-IN-4
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NoteResearch use only, not for human use.
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Brief DescriptionDot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor.
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DescriptionDot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor.
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SynonymsN1-[(3-Chloro-pyridin-2-yl)-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-methyl]-4-methanesulfonyl-N2-(4-methoxy-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-benzene-1,2-diamine
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorDOT1L
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Research Area——
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Indication——
Chemical Information
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CAS Number2565705-02-2
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Formula Weight661.1
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Molecular FormulaC28H27ClF2N8O5S
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Purity>98% (HPLC)
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SolubilityDMSO:245 mg/mL (370.61 mM，Need ultrasonic);H2O:< 0.1 mg/mL
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SMILESClC1=C([C@H](NC2=C(NC3=NC(OC)=NC(N4CCNCC4)=N3)C=C(S(C)(=O)=O)C=C2)C5=C6OC(F)(OC6=CC=C5)F)N=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Stauffer F, Weiss A, Scheufler C, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med Chem Lett. 2019;10(12):1655-1660. Published 2019 Dec 4. doi:10.1021/acsmedchemlett.9b00452
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